Neural Circuitry Underlying Waking Up to Hypercapnia

Neural circuitry underlying voluntary suppression of sadness.

BACKGROUND The ability to voluntarily self-regulate negative emotion is essential to a healthy psyche. Indeed, a chronic incapacity to suppress negative emotion might be a key factor in the genesis of depression and anxiety. Regarding the neural underpinnings of emotional self-regulation, a recent functional neuroimaging study carried out by our group has revealed that the dorsolateral prefront...

Neural circuitry underlying sentence-level linguistic prosody.

This study investigates the neural substrates underlying the perception of two sentence-level prosodic phenomena in Mandarin Chinese: contrastive stress (initial vs. final emphasis position) and intonation (declarative vs. interrogative modality). In an fMRI experiment, Chinese and English listeners were asked to selectively attend to either stress or intonation in paired 3-word sentences, and ...

Waking up to narcolepsy.

Narcolepsy with cataplexy, certainly one of the most fascinating problems in medicine, always seemed (to us) an unlikely candidate for an autoimmune or infectious etiology. In typical cases, the CSF is bland and MRI unrevealing. Powerful evidence (summarized in reference 1) that abnormalities of the hypocretin system contribute to narcolepsy came initially from genetic studies revealing that ca...

Neural circuitry underlying affective response to peer feedback in adolescence.

Peer feedback affects adolescents' behaviors, cognitions and emotions. We examined neural circuitry underlying adolescents' emotional response to peer feedback using a functional neuroimaging paradigm whereby, 36 adolescents (aged 9-17 years) believed they would interact with unknown peers postscan. Neural activity was expected to vary based on adolescents' perceptions of peers and feedback typ...

Waking up to Global Warming